Siberian Aronia - Under the Watchful Eye of Science
Does living in harmony with nature require a secret recipe? No, with Aronia Treasure it is only an understanding of the logic of nature. Our experience and knowledge are united under the watchful eye of science, which acts in the service of humankind, respecting natural laws. Aronia Treasure is not a substitute for your doctors, nor do act in opposition to anything they prescribe.
Free Radicals and Antioxidants
Life on Earth would not exist without oxygen, however, high concentrations of oxygen can be harmful to aerobes. The harmful effects of oxygen are manifested through oxygen radicals, which are reactive oxygen species (ROS), and which together with reactive nitrogen species (RNS) are constantly generated in our body during various physiological reactions and processes. Hyperproduction of several types of ROS is associated with a number of toxic effects. Most of these effects are associated with the hydroxyl radical, one of the most reactive types of ROS, which damages cellular components, including lipids, proteins, carbohydrates and nucleic acids, eventually leading to cell necrosis and apoptosis (cell death). Free radicals, reactive types of oxygen and nitrogen, represent a fundamental basis for the development of acute and chronic disorders, which manifest themselves as inflammatory processes, neurological disorders, cardiovascular disorders, malignant diseases and others.
The term antioxidant is defined as any substance that in small concentrations significantly slows down or prevents the oxidation of the substrate.
The importance of antioxidant activity may be observed through:
- prevention of nutrient oxidation during digestion and formation of gases and toxins,
- stimulation of synthesis of endogenous antioxidant enzymes and molecules,
- prevention of endogenous ROS and RNS,
- prevention of lipid peroxidation,
- prevention of activation proinflammatory enzymes, cytokines and interleukins,
- prevention of oxidative DNA damage and prevention of carcinogenesis.
In recent years, there has been a growing interest in fruits and vegetables that contain high concentrations of polyphenols, due to their potential biological and health benefits, in part related to their antioxidant capacity. Particularly interesting among the polyphenols are: anthocyanins, flavonols, flavan-3-oli, proanthocyanidins and phenolic acids.
Polyphenols are secondary metabolites of plants where they play multiple roles:
- sensory properties such as color, aroma or taste,
- influence on plant resistance to diseases and microorganisms,
- indirect influence of some polyphenols on plant growth and protection of sensitive cell areas from harmful radiation (absorption of UV radiation).
Anthocyanins and proanthocyanidins are among the main groups of compounds in the berries of Siberian Aronia, which became the subject of extensive research in the second half of the twentieth century. Both groups of compounds have shown pronounced antioxidant effects, so it can be stated with certainty that Siberian Aronia has the highest antioxidant power compared to other fruits (and their juices) rich in polyphenols and vitamins C, E, beta-carotene, as well as in relation to known synthesized antioxidants (e.g., butylated hydroxytoluene and hydroxyanisole). Various methods have been used in studies and experiments, such as determination of the chemical composition of different types of fruit and their ability to act as a "catcher" of free radicals (the capacity of anthocyanins to perform as "catcher" of free radicals was proven in studies using an extremely stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical), as well as the ability to inhibit the autoxidation of methyl linoleate (important for the prevention of LDL peroxidation, which leads to the onset of early atherosclerotic changes), and many others. Another relevant method is the determination of ORAC (Oxygen Radical Absorbance Capacity), which involves finding the antioxidant capacity and is based on the principle that the antioxidants present in the sample (e.g. anthocyanins) will prevent a decrease in fluorescence intensity of a fluorescent probe. The antioxidant capacity of Siberian Aronia was also measured in vivo by measuring various biochemical markers: SOD, TBARS, GSH.
Inflammation is the response of living tissue to endogenous and exogenous harmful factors. This vital protective mechanism, by which the organism tries to get rid of the harmful agent or to localize the damage, includes a series of changes that take place in the blood vessels, blood and in the intercellular matrix. The shape, severity and course of the inflammatory process depend on the type and intensity of the harmful agent, the type of tissue and the general condition of the organism. The inflammatory reaction can be caused by physical stimuli such as heat, cold, ionizing radiation and mechanical damage, and the extent of the change in the tissues will depend on the duration and intensity of their action. Chemical compounds - such as acids, bases and some toxic substances and drugs - also cause acute inflammation, and their concentration and retention time in the tissue determine the intensity of the inflammatory reaction. The vast majority of these causes result in the accelerated production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) on the one hand, and reduced synthesis of endogenous antioxidant enzymes and molecules on the other. As a result, proinflammatory enzymes, cytokines and interleukins are activated. In addition to antioxidant properites, the active principles of Siberian Aronia also have an exceptional anti-inflammatory effect, which implies effective action on the entire complex cascade of inflammation.
Antimutagenic and anticancer effects
ROS and RNS, as in most diseases, are known to play a key role in the pathogenesis of cancer. There is ample evidence that the endogenous antioxidant defense system is completely depleted in cancer patients (total glutathione, cysteine, and cysteinylglycine levels are reduced by up to 50%). It has also been shown that both chemo and radiotherapy induce the formation of ROS and RNS, leading to DNA damage and / or rupture. By way of its antioxidant properties, Siberian Aronia inhibits mutagenesis (shown in studies through benzo-α-pyrene, 2-aminofluorene, N-nitrosamine) due to the structure and ability of polyphenols to chelate, and on the other hand stimulates the synthesis of endogenous antioxidant enzymes, through the activation of cellular kinase.
An anti-inflammatory mechanism is also involved in antimutagenic and anticancer effects. The active principles of Siberian Aronia induce apoptosis of tumor cells by stopping the G1 / G0 and G2 / M phases of cell division. The induction of apoptosis includes multiple mechanisms, which we will not enumerate on this occasion, but can be found in more detail in available scientific studies. It should be emphasized that apoptosis of healthy cells does not occur. The mechanism itself has not yet been fully understood, but it is thought to be caused by the different gene expression of healthy and tumor cells. Activation of the immune system occurs through enhanced lymphocyte transformation, improved lysosomal enzyme activity, and increased phagocytosis ability of macrophages. By inhibiting sulfotransferases, the active principles of Siberian Aronia inhibit estrogen-induced carcinogenesis. In addition, Siberian Aronia reduces the acidity of the body, performs effective detoxification of the liver, prevents hepatotoxic inflammation of the liver and enables regular treatment. Due to organically bound iron, the presence of sufficient amounts of vitamin C and folic acid, it regulates blood test results in a short time interval, without feeling nausea, bloating and constipation. Also, the number of leukocytes decreases in a relatively short time interval.
Backed by valuable knowledge and experience - in flawless conditions, by cold pressing in a closed system according to the latest HACCP standard, without any preservatives, additives, emulsifiers or added sugar and without the presence of gluten - doctors and food technologists have managed to produce the juices of Aronia Treasure from Siberian Aronia, which grows in the north of the Eurasian continent, in an area at least 500 miles from the first industrial zones and at sub-freezing temperatures for most of the year, providing quality not available to most people in everyday shopping at farmers’ markets and supermarkets.
Measurements at Brunswick Laboratories have shown that the Aronia Treasure antioxidant level of ORAC6 is over 20,000 μmolTE at the recommended daily dose of 50 ml. One bottle of Aronia Treasure contains 750 ml of juice, which is enough for two weeks of consumption. Once opened, a bottle should be kept in the refrigerator.
Siberian Aronia juice is available on the American market. More information about the products themselves, methods of purchase, points of sale and cooperation through distribution and sales, can all be found on the website, or by contacting the importer ArmedinaUSA: 650- 666-2444
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